Gary Brecka, world renowned Human Biologist feels indentifying high homocysteine is key to managing long term health. By dealing with his increased homocysteine levels, Brecka supported Dana White by increasing his current life expectancy of only 10 years.

Homocysteine / Methylation Profile is a live blood test. If you wish to order the methylation genetic DNA test click HERE

This test provides a functional assessment of the phenotypic expression of common SNPs (MTHFR, MS, CBS) by evaluating the plasma levels of methionine, cysteine, SAM, SAH, homocysteine, adenose and cystathionine. It also provides the important methylation index, a ratio of SAM to SAH.

Normal methionine metabolism is critical for methylation, transsulfuration and folate-dependent transmethylation. Abnormal metabolism of methionine can be found in anyone at any age. It is usually associated with genetic or nutritional deficiencies, ageing and exposure to environmental toxicants.

Q. You offer a cheek swab methylation test - how is this different?

This blood test will not give you information on your genetic mutations. It will give you information on your current levels of certain markers within the methylation cycle so you get a ‘live’ picture of nutrient requirements.

Which Conditions Could This Test Help Me With?

Autism
Birth Defects
Cancer
Cardiovascular Disease
Congenital Heart Disease
Detoxification Impairment
General Health and Longevity
Genetic Disorders
Immune Dysfunction
Neurodegenerative Diseases
Nutritional Deficiencies
Psychiatric Disorders

Q. How do you support me with my results?

In ADDITION to your lab report we provide the following options which are INCLUDED in the package prices;

A) Follow up personalised written report produced by our clinical team (click HERE for team info) highlighting dietary and lifestyle advice plus links to supplement protocols, specific doses and any further testing requirements included. We use the patient information you provide us at checkout along with your results to compile personalised action points for you.

OR

B) Follow up 30-minute video call to discuss your results and answer any questions you have. Once the lab has completed your results you will be sent these via email with a link to book a time and day online. You will also then be given the option to upgrade your 30-minute call to a 45-minute call for an additional £30 if you wish. During the call your practitioner will explain the results in more detail and what they mean for you. After your call you are sent a personalised list of supplements & the dose your practitioner advises with links to purchase from our supplements store. This is for your convenience. You are of course welcome to purchase supplements elsewhere. You will also be provided with a list of follow up tests should this be required plus a copy of your recorded zoom call which you can download and keep.

OR

C) Both Zoom call and written report with personalised next steps (Zoom call is first and written report follows).

Methylation: Methionine is first enzymatically converted to S-adenosylmethionine (SAM), the principal methyl donor for methylation of DNA, RNA, protein, phospholipids, creatinine and neurotransmitters. S-adenosylhomocysteine (SAH) is generated as a product of all SAM-dependent methylation reactions and is hydrolyzed to homocysteine (Hcy) and adenosine through a reversible reaction (AHCY). SAH is a potent inhibitor of all SAM-dependent methylation reactions. Efficient removal of adenosine and Hcy is imperative to prevent accumulation of SAH. The enzymatic activities of adenosine kinase, adenosine deaminase and 5'-nucleosidases contribute to maintaining normal levels of adenosine.

Transmethylation: Hcy is normally primarily removed or recycled by remethylation to methionine through a series of reactions that require 5-methyltetrahydrofolate, B12 and betaine to complete the normal methionine cycle. A low ratio of SAM to SAH is a sensitive indicator of under-methylation. elevated plasma Hcy is an independent risk factor for cardiovascular disease (CVD). Recent research suggests that elevated SAH may be an even better predictor of risk for CVD.

Transsulfuration: Methionine > Homocysteine > Cysteine The methionine transsulfuration pathway occurs primarily in the liver and kidneys, and diverts Hcy away from remethylation to methionine toward synthesis of conditionally essential amino acid cysteine, essential sulfate, taurine and glutathione. Homocysteine in the presence of serine and B6 is enzymatically converted to cystathionine and ultimately cysteine. Cysteine is the rate-limiting amino acid in the biosynthesis of quintessential glutathione (GSH). GSH is pivotal in the regulation of intracellular redox homeostasis, oxidative stress, immune function, DNA synthesis and repair. apoptosis and detoxification of metals and chemicals. The DDI Methylation Profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy, adenosine and cystathionine, and provides the important "methylation index," a ratio of SAM to SAH.
The test results can facilitate appropriate individualized interventions to improve or normalize methionine metabolism and ameliorate or prevent adverse consequences associated with inadequate methylation and/or transsulfuration capacity.

Analytes

• Cystathionine

• Cysteine

• Homocysteine

• Methionine

• s-adenosylhomocysteine;plasma

• s-adenosylmethionine; plasma

• SAH

• SAM

  14-day turnaround time for labs to produce your report. This test requires a full blood sample. Click here to find a phlebotomist in your area. All providers listed under "Find a blood draw" are wholly independent from Body Fabulous and their fees are not included within the test prices. Please note the cost of your blood draw is payable directly to your nurse provider (approx £40-£100). Please check before making your appointment that the clinic or provider offers centrifugation.

• Your kit is posted to you from the UK within 24-48 hours of ordering so you should receive your test kit within a few days via DHL. You can then arrange for DHL to collect your sample using the freepost returns.

• Please take kit box and instructions to your chosen phlebotomist, and request a centrifuged sample. Please note you must arrange your phlebotomist appointment independently and pay your service provider directly. Book your blood to be drawn and collected Monday to Thursday only ensuring the next day is not a bank holiday or weekend in the UK. Note: On returning home from your phlebotomy appointment pop your bloods and the gel pack in the freezer before arranging your returns.

  Preparation • Fast for 12 hours before your blood test • Do not stop any medications. For 48 hours prior to the collection, discontinue taking dietary supplements containing methionine, cysteine, SAMe, and vitamins containing folate unless otherwise directed by your physician. Please only send samples back Mon-Thurs.

• Click HERE to view sample report

• Click HERE to view sample instructions

• You can read about Methylation support HERE