Weightloss Injections - Nutritional Considerations.

/

Introduction
Wegovy (semaglutide), Mounjaro (tirzepatide), and Ozempic (semaglutide) are all GLP-1 receptor agonists and are primarily used for managing blood sugar in type 2 diabetes but have recently gained attention for their effectiveness in weight loss. These drugs mimic natural GLP-1, which helps regulate insulin secretion, slow gastric emptying, and decrease appetite by acting on specific receptors in the gut and brain. Although they share similar mechanisms, each drug varies in their activity:

·        Ozempic, initially approved for type 2 diabetes, can also aid weight loss but primarily focuses on blood sugar regulation at a lower dose of semaglutide.

·        Wegovy is FDA-approved specifically for weight loss and contains a higher dose of semaglutide than Ozempic, impacting appetite, energy balance, and food intake more significantly.

·        Mounjaro is a dual agonist targeting both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual-action potentially enhances both blood sugar control and weight loss benefits, potentially offering greater metabolic improvement than single GLP-1 agonists.

Nutritional Considerations

Due to the effects and side effects of GLP-1 drugs, certain supplements may support patients' health and address common challenges:

Magnesium Glycinate: GLP-1 drugs often cause constipation due to slower gastric emptying. Magnesium glycinate, a gentle form of magnesium, can help alleviate this by promoting bowel movements. Magnesium also plays a role in relaxing the gastrointestinal muscles and can improve sleep quality when taken at night (Rosique et al., 2016).
https://www.mybodyfabulous.co.uk/shop-online/magnesium-glycinate-pure-encapsulations

Vitamin B12: GLP-1 drugs can lower energy levels by influencing B12 absorption, partly due to reduced stomach acid secretion. Low B12 can contribute to fatigue and mood disturbances (Altun et al., 2020). Supplementation with B12, especially in forms like methylcobalamin, can help maintain adequate energy levels and cognitive function.
https://www.mybodyfabulous.co.uk/shop-online/readisorb-liposomal-methyl-b12-b-12-spray-mb12

 

Probiotics: GLP-1 drugs interact with gut hormone receptors, potentially impacting the gut microbiome. Strains like Lactobacillus and Bifidobacterium support gut health and aid digestion by improving bacterial balance, which can enhance nutrient absorption and immune function (Zmora et al., 2018).
https://www.mybodyfabulous.co.uk/digestion/symprove

Thyroid Support: Although rare, there is a slight increase in the risk of thyroid cancer among GLP-1 users. Nutritional thyroid support, such as adequate iodine intake from sea vegetables, selenium from foods like Brazil nuts, and zinc, can support optimal thyroid function.
https://www.mybodyfabulous.co.uk/respiratory-circulation/thyroid-synergy-120-capsules

Vitamin D and Calcium: GLP-1 drugs have been linked to changes in bone density over time. Vitamin D and calcium are essential for bone health, especially during weight loss phases, where bone mineral density may decline. Daily vitamin D intake is often recommended to maintain adequate serum levels and support calcium absorption (Lips, 2010).
https://www.mybodyfabulous.co.uk/shop-online/calcium-citrate
https://www.mybodyfabulous.co.uk/shop-online/lvd2-liposomal-vitamin-d3-cherry-flavour-60ml-lipolife

Iron: For some individuals, iron deficiency may become more pronounced due to reduced dietary intake or absorption changes. Low iron can lead to fatigue and reduced exercise capacity. An iron supplement, preferably with vitamin C for absorption, can help maintain adequate levels (Rimon et al., 2005).
https://www.mybodyfabulous.co.uk/shop-online/liposomal-iron-capsules-30s-lipolife

Conclusion

GLP-1 receptor agonists offer an effective route to weight management, yet they can introduce nutrient deficiencies or digestive side effects. Supplements like magnesium, B12, probiotics, and vitamin D can help mitigate some of these side effects, while iron, calcium, and thyroid-supporting nutrients maintain overall well-being. With these supplements, individuals can better manage their health and enhance the positive effects of GLP-1 drugs. Always consult a healthcare professional before starting any supplement regimen, especially when taking medications.

References

  • Altun, R. et al. (2020). Impact of GLP-1 agonists on B12 absorption. Diabetes & Metabolism Journal.

  • Lips, P. (2010). Worldwide status of vitamin D nutrition. The Journal of Steroid Biochemistry and Molecular Biology.

  • Rimon, E., et al. (2005). Low B12 and iron in GLP-1 therapy. American Journal of Clinical Nutrition.

  • Rosique, R., et al. (2016). Magnesium and gastrointestinal health. Journal of Magnesium Research.

  • Zmora, N., et al. (2018). Probiotics and gut health in GLP-1 use. Nature Medicine.