Methylation is a crucial biochemical process that influences numerous aspects of health, from regulating gene expression to detoxifying harmful substances. Impaired methylation can lead to conditions such as cardiovascular disease, mood disorders, hormonal imbalances, and pregnancy complications. Elevated homocysteine levels, due to common genetic polymorphisms like MTHFR, are associated with an increased risk of heart disease, stroke, and reproductive challenges. Fortunately, supplementing with methylated nutrients like 5-MTHF, methylcobalamin, and SAMe can help bypass these genetic inefficiencies, promoting better health outcomes, particularly during pregnancy and fertility.